Treatments of
iovera Therapy
iovera Therapy
What Is iovera
A Handheld Device That Provides Targeted, Long-Lasting Pain Relief Through Cryoneurolysis
We are now performing Iovera for our knee replacement patients both pre-op and post-op, as well as for those with knee osteoarthritis pain who are not medical candidates for surgery.
See it here
in action
Womac Pain Score
iovera
Up To 56% reducation in WOMAC pain score form baseline1
Treatment with ivoera0 helped patients get moving1*
-
Significant improvements in physical function demonstrated at
Day 30 (P=0.001), Day 60 (P=0.04) and Day 90 (P=0.0017) - Significant reduction in stiffness at Day 90 (P=0.03)
30 Days
P=0.004
54%
31%
60 Days
P=0.0176
54%
39%
90 Days
P=0.0061
56%
37%
iovera0 group
iovera0 group
The most common side effects were bruising, numbers,
redness, tenderness on palpation, and swelling
2021 Aaos Cpg
Knee pain Clinical Practice Guideline cite Radnovich as a “high quality tudy1“
Study Design
Randomized, double-blind, sham-controlled, multicenter trial with a 6-month follow-up in patients with knee OA. Patients were randomized 2:1 to crtoneurolysis targeting the infrapatellar branch of the saphenous nerve (ISN) or sham treatment
(N=180; 121 in active group, 59 received sham).
In patients with OA knee pain
Reduced Pain And Improved
Movement Up To 90 Days
TARGETED COLD is applied
directly to a peripheral nerve
ivoera uses nitrous oxide and the body’s own fluid to create A PRECISE COLD ZONE UNDER THE SKIN cold enough to immediately prevent the nerve from sending pain signals without causing damage to the surrounding structures
THE EFFECT ON THE NERVE IS TEMPORARY, providing pain
relief until the nerve regenerates and function is restored
THE iovera TREATMENT DOES
NOT INCLUDE
the injection of opioids
PAIN RELIEF can last up to 90 days
per treatment
Dr. Holseth discussing Iovera for targeted cold treatment to provide pain relief without opioids
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FAQ
Frequently
Asked Questions
iovera® therapy is a non-surgical pain treatment that uses targeted cold (cryoneurolysis) to temporarily interrupt pain signals from specific nerves.
The treatment applies controlled cold to a peripheral nerve, safely stopping pain signal transmission while preserving normal nerve structure.
iovera® is commonly used for knee pain, arthritis, sports injuries, and pre- or post-surgical pain management.
Yes. iovera® therapy is FDA-cleared and does not involve medications, steroids, or opioids.
